Tissue mechanics lab



Tissue Mechanics is a discipline that seeks to understand the relationships between:

  1. Bulletthe detailed architectural structure of tissues (and their replacements) &

  2. Bullettheir biomechanical behavior in physiology, pathology, and surgery.

Historically, tissue mechanics has been most concerned with connective tissues: the tough materials that bear the highest mechanical forces in the body: bones, tendons and ligaments, cartilage, arteries, heart valves, pericardium, dura mater, intestinal and bladder wall, airways and alveoli, muscle, skin, etc. That’s not all, though. Even the so-called soft organs of the body like the brain, liver, and spleen are subject to mechanical damage in trauma, from car accidents to explosions to sports injuries. Nearly every aspect of the business of life and its risks involves biomechanical loads being placed on the body’s tissues. How they cope with those loads—and what happens when they cannot—are the matters that concern us.


In the Tissue Mechanics Lab, we’re pursuing problems of physiology: that is, how the systems of the body are controlled and coordinated for important purposes. We’re interested in developmental and reproductive biology: how the mother and fetus change during pregnancy, and how both change after birth is complete. Finally, we are interested in the coupled problems of how disease can damage biomechanically important tissues (their pathology), and how tissue engineering and regenerative medicine can provide means to replace and renew structures. It is our conviction that regenerative medicine will best succeed when it is buttressed by strong basic science knowledge of how tissues work, how they develop, and how they fail.


Tissue Mechanics & BME

The Tissue Mechanics Lab is part of the
School of Biomedical Engineering at Dalhousie University in Halifax, NS.